The trio made their major debut in June 2021 with the single "Maybe...YES EP".
On February 1, at the first concert of E-girls' final tour E-girls PERFECT LIVE 2011▶2020, Yokoi Rui, Yamashita Yuna and Sato Hinata were introduced as 3 vocalists of LDH's new girl group "iScream".
On February 19, it was revealed that the three vocalists of the group would be in charge of the ending theme song titled "Maybe...YES" for the Amazon Prime Video drama Ochanigosu. starring Suzuki Nobuyuki.
On April 22, the debut date of the group with their first single "Maybe...YES EP" was announced as June 23, 2021. Additionally, the group pre-released the title song of the single digitally on June 1.
On July 9, the documentary movie iScream Document Movie ~Scream Our Dreams~, which depicts the story of the members from their audition to the debut, started being distributed on iScream's official YouTube channel. While the first episode was released at 13:00 (1 pm), the following episodes would be released every Friday at 20:00 (8 pm).
On August 11, they held their first online live concert titled iScream Debut Online LIVE Show Case, which was broadcasted live simultaneously on their YouTube channel and LDH's video distribution service CL. During the show case, it was announced that they will release their second single "himawari" on September 3.
In February, they became the first collaboration partner of "Sings", an original short video series by Rolling Stone Japan. The magazine selected Western songs that they wanted the group to sing and arranged them a cappella, with the theme of the songs changing every month.
- Studio Albums
- [2022.04.20] i
- [2021.06.23] Maybe...YES EP
- Digital Singles
- Pre-release Digital Singles
- [2021.11.18] V.A. - Kinou Yori Akaku Ashita Yori Aoku -CINEMA FIGHTERS project- (#3 "Ai Dake wa...")
- [2021.08.11] iScream Debut Online LIVE Show Case
- Tours Featured In
-  E-girls PERFECT LIVE 2011▶2020 (Opening act)
- Concerts Featured In
- [2021.12.31] LIVE×ONLINE COUNTDOWN 2021▶︎2022 (Opening act)
- [2022.03.05, 2022.03.06] EXILE 20th ANNIVERSARY EXILE LIVE TOUR 2021 "RED PHOENIX" (Opening act)
- Digital Shows
- [2021.07.09 - Present] iScream Document Movie ~Scream Our Dreams~
- [2021.07.06 - Present] LAUGH & MUSIC ROOM ~iScream Voice~ (FM Osaka, Tuesday 5:30AM)
- [2022.01.01] iScream's All Night Nippon 0 (ZERO)
- The group's name is a play on the pronunciation of words of English and Japanese origin. On one hand, it means "I scream" (私 ( I ) が叫ぶ), on the other hand, it means "Scream Love" (愛 ( Ai ) を叫ぶ). Additionally, interpreting the name as "Ice Cream" could indicate the group's fresh and sweet concept.
- The art director of the group is artist Yamaguchi Harumi, a pioneer of realistic illustration. The art visual was drawn with an airbrush by her, and she is also in charge of the album/single covers of the group.
- The overall theme of her artwork is "emancipated women".
- The album/single covers are reworked versions of her previous art pieces.
- HINATA is the only member that was not part of EXPG Lab and its project group KIZZY.